Chengwen Sun, MD, PhD

      Telephone:            (701) 231-6454 (office),   

                                  (701) 231-6455 (lab)

      Fax:                       (701) 231-8333,

      Email: Chengwen.Sun@ndsu.edu          

 

EDUCATION:

1983-1988   M.D.  Medicine,   Norman Bethune University of Medical Sciences, China

1990-1996   Ph.D.  Immunology, Norman Bethune University of Medical Sciences, China

1996-2000    Postdoctoral Fellow, Department of Physiology, Medical College of Wisconsin,

                     Milwaukee, WI         

2000–2005   Postdoctoral Associate, Department of Physiology, College of Medicine,

                     University of Florida, Gainesville, FL

 

PROFESSIONAL EXPERIENCE:

1988 - 1990          Fellow, Department of Cardiology, Norman Bethune University of

                             Medical Sciences, Jilin, China. 

2005 - 2007          Research Assistant Professor, Department of Physiology and

                             Functional genomics, University of Florida. Gainesville, FL

2007- Present       Assistant Professor, Department of Pharmaceutical Sciences, College

                             of Pharmacy, North Dakota State University, Fargo, ND.

 

RESEARCH EXPERIENCE:

I have studied hypertension in three related different systems (cardiovascular, renal, and neural) at multiple levels (in vivo, in vitro, cellular and molecular). My current research is focused on central blood pressure regulation and pathogenesis of hypertension to identify novel targets for the treatment of hypertension and other cardiovascular diseases. Then, based on the molecular structures of these target proteins, we are going to develop novel pharmaceutical tools for the clinical use in these diseases.

 

TEACHING EXPERIENCE:

Cardiology                                                    Lectures                                     1988-1990

Medical Physiology                                       Lectures                                     2005-2007

Cardiovascular Pharmacology                       Lectures                                     2007-present

 

PUBLICATION (In Last 3 Years):

  1. Sun C, Li H, Leng L, Raizada MK, Bucala R, Sumners C. Macrophage migration inhibitory factor: an intracellular inhibitor of angiotensin II-induced increases in neuronal activity. J Neurosci. 2004 Nov 3;24(44):9944-52.
  2. Sellers KW, Sun C, Diez-Freire C, Waki H. Morriseau C, Falck JF, Hammock BD, Paton JF, Raizada MK. Novel mechanism of brain soluble epoxide hydrolase-mediated blood pressure regulation in the SHR. FASEB J, 2005 19(6): 626-628.
  3. Sun CW, Sellers KW, Sumners C, Raizada MK. NAD(P)H oxidase inhibitor attenuates neuronal chronotropic actions of Angiotensin II. Circ Res 2005 96: 659-666.
  4. Matsuura T, Sun C, Leng L, Kapurniotu A, Bernhagen J, Bucala R, Martynyuk AE, Sumners C. Macrophage migration inhibitory factor increases neuronal delayed rectifier k+ current. J Neurophysiol. 2006 Feb;95(2):1042-8.
  5. Yamazato M, Yamazato Y, Sun C, Diez-Freire C, Raizada MK.  Overexpression of angiotensin-converting enzyme 2 in the rostral ventrolateral medulla causes long-term decrease in blood pressure in the spontaneously hypertensive rats. Hypertension. 2007 Apr;49(4):926-31.
  6. Sun C, Li H, Gao Y, Matsuura T, Upchurch PA, Raizada MK, Sumners C. Lack of macrophage migration inhibitory factor regulation is linked to the increased chronotropic action of angiotensin II in SHR neurons. Hypertension. 2007 Mar;49(3):528-34.
  7. Yao FR, Sun C. Crosstalk between the Angiotensin and GABA systems in NTS neurons: contribution to the long-term control of blood pressure. Am J. Physi. . (in press).
  8. Sun C. Shan Z, Raizada MK. Enhanced Apelin/APJ system in the Cardiovascular Regulatory Brain Regions of Spontaneously Hypertensive Rats. Hypertension. (in press)

 

Professional Communications (In Last 3 Years):

  1. Angiontensin II-induced increases in neuronal firing rate: role of ROS. FASEB Journal 2004; 18: A1258; 834.3.
  2. Macrophage migration inhibitory factor (MIF) prevents the neuronal chronotropic action of Ang II via a thiol oxidoreductase mechanism. FASEB Journal 2005; 19: A619; 359.4.
  3. Macrophage migration inhibitory factor (MIF) increases neuronal delayed rectifier K+ current. FASEB Journal 2005; 19: A619; 359.5.
  4. Crosstalk between the Angiotensin and GABA systems in NTS neurons: contribution to the long-term control of blood pressure. Hypertension; 2005; 46: LB11.
  5. Chronotropic actions of angiotensin II are mediated by a PKC-dependent activation of NADPH oxidase in brain neurons. Hypertension; 2006: 48. (Oral presentation)
  6. PKC-dependent phosphorylation of p47phox is involved in the chronotropic action of angiotensin II in neurons. Neuroscience meeting 2006.
  7. Increased expression of Apelin and its receptor APJ in the cardiovascular regulatory brain regions of spontaneously hypertensive rats. Endocrine Society meeting, Toronto. June 2-5, 2007.
  8. Interaction between Ang II and GABA system in NTS: Central resetting of blood pressure in hypertension. Experiment Biology Meeting, Washington, DC. April 28-May 2, 2007.
  9. Enhanced Apelin/APJ system in the Cardiovascular Regulatory Brain Regions of Spontaneously Hypertensive Rats. Hypertension; 2007; 50

 

RESEACH SUPPORT:

The overall objective for this study is to investigate the role of Apelin in the cardiovascular regulation and pathogenesis of hypertension in brain RVLM 

 

2.    American Heart Association (PI: Sun):                                           

      AHA National:  “Long-term Blood pressure regulation: Angiotensin II and GABA”

           The overall objective of this project is to investigate the central mechanisms of

            long-term blood pressure regulation mediated by the interaction between  

            Angiotensin II and GABA in the NTS.